Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 17, Issue 8, Pages 948-U55Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1877
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Funding
- US National Institutes of Health [R01 GM088506]
- Medical Research Council [G0300723B, G0800784, G0800784B] Funding Source: researchfish
- MRC [G0800784] Funding Source: UKRI
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One X chromosome, selected at random, is silenced in each female mammalian cell. Xist encodes a noncoding RNA that influences the probability that the cis-linked X chromosome will be silenced. We found that the A-repeat, a highly conserved element within Xist, is required for the accumulation of spliced Xist RNA. In addition, the A-repeat is necessary for X-inactivation to occur randomly. In combination, our data suggest that normal Xist RNA processing is important in the regulation of random X-inactivation. We propose that modulation of Xist RNA processing may be part of the stochastic process that determines which X chromosome will be inactivated.
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