Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 17, Issue 7, Pages 891-893Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1859
Keywords
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Funding
- Spanish Ministerio de Ciencia e Innovacion [BFU2006-09593, BFU2009-07134, BIO2009-10576, BFU2008-02372, FIS-PI070045]
- Generalitat de Catalunya [SGR2009-1366, SGR2009-1309]
- European Community [LSHG-2006-031220]
- CSIC
- Ministerio de Ciencia e Innovacion
- Academy of Finland
- Tampere University Hospital Medical Research Fund
- Sigrid Juselius Foundation
- ICREA Funding Source: Custom
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The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(UUR)(Leu) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.
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