4.5 Article

Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

Journal

NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 17, Issue 7, Pages 891-893

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1859

Keywords

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Funding

  1. Spanish Ministerio de Ciencia e Innovacion [BFU2006-09593, BFU2009-07134, BIO2009-10576, BFU2008-02372, FIS-PI070045]
  2. Generalitat de Catalunya [SGR2009-1366, SGR2009-1309]
  3. European Community [LSHG-2006-031220]
  4. CSIC
  5. Ministerio de Ciencia e Innovacion
  6. Academy of Finland
  7. Tampere University Hospital Medical Research Fund
  8. Sigrid Juselius Foundation
  9. ICREA Funding Source: Custom

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The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(UUR)(Leu) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.

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