Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 17, Issue 11, Pages 1289-1290Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1110-1289
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The interaction of the Fas death domain (DD) with the adaptor protein FADD is a critical step in assembling the death-inducing signaling complex (DISC). Using structural and biophysical approaches, two recent papers reveal the core stoichiometry to be a 5Fas:5FADD complex.
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