Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 16, Issue 2, Pages 226-228Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1527
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Funding
- US National Institutes of Health [GM60987]
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Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG repeats in a length-dependent manner in primate cells and in yeast. Saccharomyces cerevisiae proteins Tof1 and Mrc1 facilitate replication fork progression through CGG repeats. Remarkably, the fork-stabilizing role of Mrc1 does not involve its checkpoint function. Thus, chromosomal fragility might occur when forks stalled at expanded CGG repeats escape the S-phase checkpoint.
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