4.5 Editorial Material

Reading and writing DNA methylation

Journal

NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 15, Issue 10, Pages 1003-1004

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1008-1003

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By recruiting the Dnmt1 DNA methyltransferase to hemimethylated DNA, the ubiquitin-like with PHD and ring finger domains 1 (UHRF1) protein plays an important part in DNA methylation. The structures of the SRA domain of UHRF1 in complex with hemimethylated DNA show that the methylated cytosine is flipped out of the DNA helix, as observed previously with DNA methyltransferases.

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