Journal
NATURE REVIEWS UROLOGY
Volume 9, Issue 3, Pages 131-137Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrurol.2012.10
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Funding
- NCI NIH HHS [R01 CA162383] Funding Source: Medline
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Oncogenic activation of ERG resulting from gene fusion is present in over half of all patients with prostate cancer in Western countries. Although the underlying genetic mechanisms have been extensively studied, evaluation of the ERG oncoprotein-the translational product of ERG gene fusions-has just begun. The robust correlation between ERG oncoprotein detection and gene fusion status enables rapid characterization of this protein in large patient cohorts. Recent studies have focused on characterizing the ERG oncoprotein and determining its potential role in the diagnosis and biological stratification of prostate cancer.
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