Journal
NATURE REVIEWS RHEUMATOLOGY
Volume 6, Issue 6, Pages 317-325Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrrheum.2010.60
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Funding
- NIAID NIH HHS [R01 AI042269-14, R03 AI053463, R01 AI049954-09, R01 AI049954, R01 AI042269, P01 AI065687-05, P01 AI065687, R03 AI053463-01A1] Funding Source: Medline
- NIAMS NIH HHS [K23 AR055672-02, K23 AR055672] Funding Source: Medline
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T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus erythematosus (SLE), and seem to be directly involved in the development of related organ pathology. Defects associated with CD8(+) and T-regulatory (T-REG) cell function manifest in parallel with the expanded CD3(+)CD4(-)CD8(-) T cell lineage. The cytokine expression pattern is uniquely characterized by decreased expression of interleukin (IL)-2 and increased production of IL-17 and related cytokines. Therapeutic approaches that limit the cognate interaction between T cells and B cells, prevent inappropriate tissue homing and restore T-REG cell function and the normal cytokine milieu have been entertained. Biochemical characterization of SLE T cells has revealed distinct early and late signaling aberrations, and has enabled the identification of novel molecular targets that can be corrected with small molecules, and biomarkers that may foretell disease activity and predict organ damage.
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