Journal
NATURE REVIEWS RHEUMATOLOGY
Volume 5, Issue 10, Pages 554-559Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrrheum.2009.178
Keywords
-
Categories
Funding
- National Health & Medical Research Council of Australia [461243]
- NHMRC Development [305558]
- NHMRC Peter Doherty Fellowship [310608]
- NHMRC Industry Fellowship [461287]
- NHMRC Clinical Practitioner Fellowship [461203]
Ask authors/readers for more resources
Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are well-recognized regulators of hematopoiesis and have an established role as growth factors in clinical practice. G-CSF and GM-CSF regulate myeloid cell production, differentiation and activation, and might also be important for driving inflammatory responses. Inappropriate engagement of this pathway could be a critical amplification mechanism when maladaptive immune responses predispose to autoimmunity and sterile tissue inflammation. We postulate that antagonism of G-CSF or GM-CSF could represent a novel therapeutic approach for a variety of autoimmune-mediated inflammatory diseases, including rheumatoid arthritis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available