Journal
NATURE REVIEWS NEUROSCIENCE
Volume 19, Issue 10, Pages 622-635Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41583-018-0057-5
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Funding
- US National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke [R01 NS088137, R21 NS104609, R21 NS101673]
- National Institute on Aging (NIA) [R01 AG051812, R01 AG054672]
- National Eye Institute [R01 EY027921]
- National Multiple Sclerosis Society [5092A1]
- Nancy Davis Foundation Faculty Award
- Cure Alzheimer's Fund Award
- Amyotrophic Lateral Sclerosis Association
- Sanofi
- US Department of Defense [AL120029]
- Thome Foundation
- NIH NIA [R01AG043975, R01AG040092]
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Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and surface protein expression pattern, which differs from that of tissue macrophages. In recent years, there have been a number of important advances in our understanding of the molecular signatures of homeostatic microglia and disease-associated microglia that have provided insight into how these cells are regulated in health and disease and how they contribute to the maintenance of the neural environment.
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