Journal
NATURE REVIEWS NEUROSCIENCE
Volume 15, Issue 8, Pages 497-506Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3730
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Funding
- G. Harold and Leila Y. Mathers Charitable Foundation
- Leona M. and Harry B. Helmsley Charitable Trust grant [2012-PG-MED002]
- NIH [TR01 MH095741]
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Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.
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