Journal
NATURE REVIEWS NEUROSCIENCE
Volume 15, Issue 1, Pages 7-18Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrn3650
Keywords
-
Categories
Funding
- US National Institutes of Health [NS014428, NS064014, NS080928]
Ask authors/readers for more resources
The remarkable ability of a single axon to extend multiple branches and form terminal arbors enables vertebrate neurons to integrate information from divergent regions of the nervous system. Axons select appropriate pathways during development, but it is the branches that extend interstitially from the axon shaft and arborize at specific targets that are responsible for virtually all of the synaptic connectivity in the vertebrate CNS. How do axons form branches at specific target regions? Recent studies have identified molecular cues that activate intracellular signalling pathways in axons and mediate dynamic reorganization of the cytoskeleton to promote the formation of axon branches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available