Journal
NATURE REVIEWS NEUROSCIENCE
Volume 14, Issue 5, Pages 365-376Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrn3475
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Funding
- British Heart Foundation
- Cancer Research UK
- Economic and Social Research Council
- Medical Research Council
- UK National Institute for Health Research under UK Clinical Research Collaboration
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A study with low statistical power has a reduced chance of detecting a true effect, but it is less well appreciated that low power also reduces the likelihood that a statistically significant result reflects a true effect. Here, we show that the average statistical power of studies in the neurosciences is very low. The consequences of this include overestimates of effect size and low reproducibility of results. There are also ethical dimensions to this problem, as unreliable research is inefficient and wasteful. Improving reproducibility in neuroscience is a key priority and requires attention to well-established but often ignored methodological principles.
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