Journal
NATURE REVIEWS NEUROSCIENCE
Volume 14, Issue 4, Pages 278-291Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3469
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Funding
- NINDS NIH HHS [R01 NS061963, NS061963] Funding Source: Medline
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I Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevetopmental, neuropsychiatric and movement disorders autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.
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