Journal
NATURE REVIEWS NEUROSCIENCE
Volume 13, Issue 3, Pages 183-193Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3176
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Funding
- UK Academic Study Group
- Institute of Advanced Studies of the Hebrew University of Jerusalem, Israel
- Israel Science Foundation
- Israel Ministry of Health
- United States-Israel Binational Science Foundation
- European Commission
- Charles E. Smith Family and Professor Joel Elkes Laboratory for Collaborative Research in Psychobiology
- Deutsches Zentrum fur Neurodegenerative Erkrankungen
- Deutsche Forschungsgemeinschaft
- International Foundation for Research in Paraplegia
- Human Frontier Science Program
- UK Medical Research Council
- Engineering and Physical Sciences Research Council
- European Union
- Plasticise and Angioscaff
- Henry Smith Charity
- Christopher and Dana Reeve Foundation
- UK National Institute of Health Research Cambridge Biomedical Research Centre
- MRC [G1000864] Funding Source: UKRI
- Medical Research Council [G1000864] Funding Source: researchfish
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The assembly of a new growth cone is a prerequisite for axon regeneration after injury. Creation of a new growth cone involves multiple processes, including calcium signalling, restructuring of the cytoskeleton, transport of materials, local translation of messenger RNAs and the insertion of new membrane and cell surface molecules. In axons that have an intrinsic ability to regenerate, these processes are executed in a timely fashion. However, in axons that lack regenerative capacity, such as those of the mammalian CNS, several of the steps that are required for regeneration fail, and these axons do not begin the growth process. Identification of the points of failure can suggest targets for promoting regeneration.
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