Journal
NATURE REVIEWS NEUROSCIENCE
Volume 13, Issue 6, Pages 380-394Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3249
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Funding
- Swiss Science Foundation [31003A-133124, CRSII3_136210]
- National Center of Competences in Research (NCCR)
- European Community [201714]
- Swiss National Science Foundation (SNF) [CRSII3_136210] Funding Source: Swiss National Science Foundation (SNF)
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GABA(B) receptors (GABA(B)Rs) are G protein-coupled receptors for GABA, the main inhibitory neurotransmitter in the CNS. In the past 5 years, notable advances have been made in our understanding of the molecular composition of these receptors. GABABRs are now known to comprise principal and auxiliary subunits that influence receptor properties in distinct ways. The principal subunits regulate the surface expression and the axonal versus dendritic distribution of these receptors, whereas the auxiliary subunits determine agonist potency and the kinetics of the receptor response. This Review summarizes current knowledge on how the subunit composition of GABABRs affects the distribution of these receptors, neuronal processes and higher brain functions.
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