Journal
NATURE REVIEWS NEUROSCIENCE
Volume 13, Issue 6, Pages 435-445Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3230
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Funding
- Glenn Foundation
- Research Into Ageing and the Biotechnology and Biological Sciences Research Council [G015147/1]
- BBSRC [BB/G015147/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G015147/1] Funding Source: researchfish
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In recent years, novel model systems have made significant contributions to our understanding of the processes that control the ageing of whole organisms. However, there are limited data to show that the mechanisms that gerontologists have identified as having a role in organismal ageing contribute significantly to the ageing of the central nervous system. Two recent discoveries illustrate this particularly well. The first is the consistent failure of researchers to demonstrate a simple relationship between organismal ageing and oxidative stress - a mechanism often assumed to have a primary role in brain ageing. The second is the demonstration that senescent cells play a causal part in organismal ageing but remain essentially unstudied in a CNS context. We argue that the animal models now available (including rodents, flies, molluscs and worms), if properly applied, will allow a paradigm shift in our current understanding of the normal processes of brain ageing.
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