Journal
NATURE REVIEWS NEUROSCIENCE
Volume 12, Issue 11, Pages 638-651Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3105
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Funding
- US National Institute on Drug Abuse (NIDA)
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The hedonic properties of food can stimulate feeding behaviour even when energy requirements have been met, contributing to weight gain and obesity. Similarly, the hedonic effects of drugs of abuse can motivate their excessive intake, culminating in addiction. Common brain substrates regulate the hedonic properties of palatable food and addictive drugs, and recent reports suggest that excessive consumption of food or drugs of abuse induces similar neuroadaptive responses in brain reward circuitries. Here, we review evidence suggesting that obesity and drug addiction may share common molecular, cellular and systems-level mechanisms.
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