Journal
NATURE REVIEWS NEUROSCIENCE
Volume 12, Issue 4, Pages 204-216Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2969
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Funding
- Institut National de la Sante et de la Recherche Medicale
- Agence Nationale pour la Recherche
- Centre National de la Recherche Scientifique
- Universite Pierre et Marie Curie
- Canadian Research chair
- Douglas Mental Health University Institute
- Canadian Foundation for Innovation
- Swedish Research Council
- Swedish Brain Foundation
- Ahlen Foundation
- Wiberg Foundation
- National Board of Health and Welfare
- Uppsala University, Sweden
- Canadian Institutes of Health Research (CIHR) [NRF-3,544]
- National Alliance for Research on Schizophrenia and Depression
- Neuroscience Canada
- Natural Sciences and Engineering Research Council of Canada
- Swedish Foundation for International Cooperation in Research and Higher Education
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Recent data indicate that 'classical' neurotransmitters can also act as co-transmitters. This notion has been strengthened by the demonstration that three vesicular glutamate transporters (vesicular glutamate transporter 1 (VGLUT1), VGLUT2 and VGLUT3) are present in central monoamine, acetylcholine and GABA neurons, as well as in primarily glutamatergic neurons. Thus, intriguing questions are raised about the morphological and functional organization of neuronal systems endowed with such a dual signalling capacity. In addition to glutamate co-release, vesicular synergy - a process leading to enhanced packaging of the 'primary' transmitter - is increasingly recognized as a major property of the glutamatergic co-phenotype. The behavioural relevance of this co-phenotype is presently the focus of considerable interest.
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