Journal
NATURE REVIEWS NEUROSCIENCE
Volume 12, Issue 5, Pages 269-283Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrn3024
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Funding
- University of Texas Southwestern Medical Centre, at Dallas, Texas, USA
- Mount Sinai School of Medicine, New York, New York, USA
- US National Institute of Mental Health (NIMH)
- National Institute on Drug Abuse (NIDA)
- Cedars-Sinai Regenerative Medicine Institute, Los Angeles, California, USA
- US National Institutes of Health (NIH)
- NIDA [DA016765, DA016765-07S, DA023555]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [DK079328]
- National Alliance for Research on Schizophrenia and Depression
- National Aeronautics and Space Administration
- Norwegian Department of Public Health
- US National Institute of Neurological Disorders and Stroke (NINDS)
- NIDA
- Kavli Institute of Neuroscience at Yale University School of Medicine, New Haven, Connecticut, USA
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The Notch pathway is often regarded as a developmental pathway, but components of Notch signalling are expressed and active in the adult brain. With the advent of more sophisticated genetic manipulations, evidence has emerged that suggests both conserved and novel roles for Notch signalling in the adult brain. Not surprisingly, Notch is a key regulator of adult neural stem cells, but it is increasingly clear that Notch signalling also has roles in the regulation of migration, morphology, synaptic plasticity and survival of immature and mature neurons. Understanding the many functions of Notch signalling in the adult brain, and its dysfunction in neurodegenerative disease and malignancy, is crucial to the development of new therapeutics that are centred around this pathway.
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