Journal
NATURE REVIEWS NEUROSCIENCE
Volume 12, Issue 7, Pages 375-387Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3025
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- Institut Nationale de la Sante et de la Recherche Medicale (INSERM)
- Agence Nationale de la Recherche (ANR)
- Fondation pour la Recherche Medicale (FRM)
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The variability of the postsynaptic response following a single action potential arises from two sources: the neurotransmitter release is probabilistic, and the postsynaptic response to neurotransmitter release has variable timing and amplitude. At individual synapses, the number of molecules of a given type that are involved in these processes is small enough that the stochastic (random) properties of molecular events cannot be neglected. How the stochasticity of molecular processes contributes to the variability of synaptic transmission, its sensitivity and its robustness to molecular fluctuations has important implications for our understanding of the mechanistic basis of synaptic transmission and of synaptic plasticity.
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