Journal
NATURE REVIEWS NEUROSCIENCE
Volume 11, Issue 5, Pages 339-350Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2822
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Funding
- James S. McDonnell Foundation
- Lookout Fund
- Kavli Institute for Brain and Mind
- NSF Temporal Dynamics of Learning Center
- US National Institutes of Health [NS-050217]
- National Institute on Aging [AG-020938]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS050217] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG020938] Funding Source: NIH RePORTER
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The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an important role for adult hippocampal neurogenesis in learning and memory, but its specific function in these processes has remained elusive. In this article, we summarize recent progress in this area, including advances based on behavioural studies and insights provided by computational modelling. Increasingly, evidence suggests that newborn neurons might be involved in hippocampal functions that are particularly dependent on the dentate gyrus, such as pattern separation. Furthermore, newborn neurons at different maturation stages may make distinct contributions to learning and memory. In particular, computational studies suggest that, before newborn neurons are fully mature, they might function as a pattern integrator by introducing a degree of similarity to the encoding of events that occur closely in time.
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