Journal
NATURE REVIEWS NEUROSCIENCE
Volume 11, Issue 6, Pages 436-449Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2809
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Funding
- HHMI
- US National Institutes of Health [NS038372]
- Whitehead Institute Regenerative Biology Initiative
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In ageing populations, neurodegenerative diseases increase in prevalence, exacting an enormous toll on individuals and their communities. Multiple complementary experimental approaches are needed to elucidate the mechanisms underlying these complex diseases and to develop novel therapeutics. Here, we describe why the budding yeast Saccharomyces cerevisiae has a unique role in the neurodegeneration armamentarium. As the best-understood and most readily analysed eukaryotic organism, S. cerevisiae is delivering mechanistic insights into cell-autonomous mechanisms of neurodegeneration at an interactome-wide scale.
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