Journal
NATURE REVIEWS NEUROSCIENCE
Volume 11, Issue 8, Pages 563-576Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2880
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Funding
- National Eye Institute and National Institute of Diabetes, Digestive and Kidney Diseases
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In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent progenitors in a conserved order and are integrated into an intricate laminated architecture. Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (ROR beta, OTX2, NRL, CRX, NR2E3 and TR beta 2) that determine rod versus M cone or S cone cell fate. We propose a step-wise 'transcriptional dominance' model of photoreceptor cell fate determination, with the S cone representing the default state of a generic photoreceptor precursor. Elucidation of gene-regulatory networks that dictate photoreceptor genesis and homeostasis will have wider implications for understanding the development of nervous system function and for the treatment of neurodegenerative diseases.
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