Journal
NATURE REVIEWS NEUROSCIENCE
Volume 10, Issue 5, Pages 383-U86Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2635
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH080332, K02MH001072, R21MH080426] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [T32DA007267] Funding Source: NIH RePORTER
- NIDA NIH HHS [T32 DA007267-14, T32 DA007267] Funding Source: Medline
- NIMH NIH HHS [R01 MH080332-02, MH080426, K02 MH001072-10, MH080332, K02MH10172, K02 MH001072, R21 MH080426, R01 MH080332, R21 MH080426-02] Funding Source: Medline
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Traditional descriptions of the cortical cholinergic input system focused on the diffuse organization of cholinergic projections and the hypothesis that slowly changing levels of extracellular acetylcholine (Ach) mediate different arousal states. The ability of Ach to reach the extrasynaptic space (volume neurotransmission), as opposed to remaining confined to the synaptic cleft (wired neurotransmission), has been considered an integral component of this conceptualization. recent studies demonstrated that phasic release of Ach, at the scale of seconds, mediates precisely defined cognitive operations. This characteristic of cholinergic neurotransmission is proposed to be of primary importance for understanding cholinergic function and developing treatments for cognitive disorders that result from abnormal cholinergic neurotransmission.
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