Journal
NATURE REVIEWS NEUROSCIENCE
Volume 10, Issue 7, Pages 507-518Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2608
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Funding
- NINDS NIH HHS [R37 NS037075-10, R37 NS037075, R01 NS037075, P01 NS031249-130004, R01 NS031978, P01 NS031249, R01 NS031978-14, NS37075, NS31978, NS31249] Funding Source: Medline
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Neurobiologists have long sought to understand how circuits in the nervous system are organized to generate the precise neural outputs that underlie particular behaviours. The motor circuits in the spinal cord that control locomotion, commonly referred to as central pattern generator networks, provide an experimentally tractable model system for investigating how moderately complex ensembles of neurons generate select motor behaviours. The advent of novel molecular and genetic techniques coupled with recent advances in our knowledge of spinal cord development means that a comprehensive understanding of how the motor circuitry is organized and operates may be within our grasp.
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