Journal
NATURE REVIEWS NEUROSCIENCE
Volume 10, Issue 1, Pages 23-36Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2533
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Funding
- NIH [DA018156, DA015642, DA015656]
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE017782] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038020, R01NS040696] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K02DA015642, R01DA017670, R01DA023132, R01DA018156, R21DA015656] Funding Source: NIH RePORTER
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Glia have emerged as key contributors to pathological and chronic pain mechanisms. On activation, both astrocytes and microglia respond to and release a number of signalling molecules, which have protective and/or pathological functions. Here we review the current understanding of the contribution of glia to pathological pain and neuroprotection, and how the protective, anti-inflammatory actions of glia are being harnessed to develop new drug targets for neuropathic pain control. Given the prevalence of chronic pain and the partial efficacy of current drugs, which exclusively target neuronal mechanisms, new strategies to manipulate neuron-glia interactions in pain processing hold considerable promise.
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