Journal
NATURE REVIEWS NEUROSCIENCE
Volume 10, Issue 12, Pages 861-872Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2735
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Funding
- Canadian Institutes of Health Research (CIHR)
- Heart and Stroke Foundation of British Columbia
- Yukon
- Heart and Stroke Foundation of Ontario
- Canadian Stroke Network
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Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and the impairment of sensation, movement or cognition. Evidence from animal models suggests that a time-limited window of neuroplasticity opens following a stroke, during which the greatest gains in recovery occur. Plasticity mechanisms include activity-dependent rewiring and synapse strengthening. The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury.
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