Journal
NATURE REVIEWS NEUROSCIENCE
Volume 10, Issue 8, Pages 573-584Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrn2682
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Funding
- National Institute of Mental Health (NIMH) [046001, 042984, 066122, 001894, 063291]
- Price Foundation
- National Institute on Drug Abuse [016663, 018307, 020687]
- Center of Excellence in Stress and Mental Health
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Individuals with anorexia nervosa have a relentless preoccupation with dieting and weight loss that results in severe emaciation and sometimes death. It is controversial whether such symptoms are secondary to psychosocial influences, are a consequence of obsessions and anxiety or reflect a primary disturbance of brain appetitive circuits. New brain imaging technology provides insights into ventral and dorsal neural circuit dysfunction - perhaps related to altered serotonin and dopamine metabolism - that contributes to the puzzling symptoms found in people with eating disorders. For example, altered insula activity could explain interoceptive dysfunction, and altered striatal activity might shed light on altered reward modulation in people with anorexia nervosa.
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