Journal
NATURE REVIEWS NEUROSCIENCE
Volume 9, Issue 6, Pages 453-466Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2401
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Funding
- NIDDK NIH HHS [R01 DK049430, DK077783, DK049430, R37 DK049430-13, R01 DK077783, R37 DK049430] Funding Source: Medline
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Micturition, or urination, occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. The neural circuitry that controls this process is complex and highly distributed: it involves pathways at many levels of the brain, the spinal cord and the peripheral nervous system and is mediated by multiple neurotransmitters. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary or reflex micturition, leading to urinary incontinence. This is a major health problem, especially in those with neurological impairment. Here we review the neural control of micturition and how disruption of this control leads to abnormal storage and release of urine.
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