Journal
NATURE REVIEWS NEUROSCIENCE
Volume 9, Issue 11, Pages 813-825Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2501
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Funding
- NIMH NIH HHS [R37 MH038256-26, R37 MH038256] Funding Source: Medline
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Silent synapses abound in the young brain, representing an early step in the pathway of experience-dependent synaptic development. Discovered amidst the debate over whether long-term potentiation reflects a presynaptic or a postsynaptic modification, silent synapses - which in the hippocampal CA1 subfield are characterized by the presence of NMDA receptors but not AMPA receptors - have stirred some mechanistic controversy of their own. Out of this literature has emerged a model for synapse unsilencing that highlights the central role for postsynaptic AMPA-receptor trafficking in the expression of excitatory synaptic plasticity.
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