Journal
NATURE REVIEWS NEUROSCIENCE
Volume 9, Issue 5, Pages 331-343Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2370
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Funding
- Medical Research Council Funding Source: Medline
- NINDS NIH HHS [R01 NS048045-04, P01 NS054900, R01 NS051195, NS046478, R01 NS056359, NS048045, R01 NS056359-03, R01 NS081986, P01NS054900, R01 NS048045, NS056359, R01 NS051195-04, R01 NS047478, P01 NS054900-020003, NS051195, R01 NS046478, R21 NS080064, R01 NS047478-05] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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GABA (gamma-aminobutyric acid) type A receptors (GABA(A)Rs) mediate most fast synaptic inhibition in the mammalian brain, controlling activity at both the network and the cellular levels. The diverse functions of GABA in the CNS are matched not just by the heterogeneity of GABA(A)Rs, but also by the complex trafficking mechanisms and protein protein interactions that generate and maintain an appropriate receptor cell-surface localization. In this Review, we discuss recent progress in our understanding of the dynamic regulation of GABA(A)R composition, trafficking to and from the neuronal surface, and lateral movement of receptors between synaptic and extrasynaptic locations. Finally, we highlight a number of neurological disorders, including epilepsy and schizophrenia, in which alterations in GABA(A)R trafficking occur.
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