Journal
NATURE REVIEWS NEPHROLOGY
Volume 9, Issue 12, Pages 705-706Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrneph.2013.221
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The potential roles for autoantibodies in renal transplantation are increasing, as illustrated by a recent report of polyreactive autoantibodies produced by B-cell clones from a kidney transplant recipient that can bind apoptotic cells and activate complement. Such autoantibodies have the potential to amplify microcirculation injury caused by alloantibody in antibody-mediated transplant rejection.
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