Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 15, Issue 4, Pages 225-242Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3775
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Funding
- US National Institutes of Health (NIH) [EY08538, EY022165, GM34107]
- Dyson
- Beckman Foundation
- Starr Foundation
- NIH [CA132898, GM50526]
- Susan Komen Breast Cancer Foundation
- Research to Prevent Blindness
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Epithelial cells require apical-basal plasma membrane polarity to carry out crucial vectorial transport functions and cytoplasmic polarity to generate different cell progenies for tissue morphogenesis. The establishment and maintenance of a polarized epithelial cell with apical, basolateral and ciliary surface domains is guided by an epithelial polarity programme (EPP) that is controlled by a network of protein and lipid regulators. The EPP is organized in response to extracellular cues and is executed through the establishment of an apical-basal axis, intercellular junctions, epithelial-specific cytoskeletal rearrangements and a polarized trafficking machinery. Recent studies have provided insight into the interactions of the EPP with the polarized trafficking machinery and how these regulate epithelial polarization and depolarization.
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