Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 15, Issue 10, Pages 647-664Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3873
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Funding
- American Cancer Society [RSG-12-141-01-CSM]
- National Institutes of Health National Cancer Institute (NIH-NCI) [U01 CA155758]
- Jerome L. Greene Foundation Discovery Project
- Mary Kay Ash Foundation [036-13]
- Cindy Rosencrans Fund for Triple Negative Breast Cancer Research
- Breast Cancer Research Foundation
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Mammalian organs are challenging to study as they are fairly inaccessible to experimental manipulation and optical observation. Recent advances in three-dimensional (3D) culture techniques, coupled with the ability to independently manipulate genetic and microenvironmental factors, have enabled the real-time study of mammalian tissues. These systems have been used to visualize the cellular basis of epithelial morphogenesis, to test the roles of specific genes in regulating cell behaviours within epithelial tissues and to elucidate the contribution of microenvironmental factors to normal and disease processes. Collectively, these novel models can be used to answer fundamental biological questions and generate replacement human tissues, and they enable testing of novel therapeutic approaches, often using patient-derived cells.
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