Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 15, Issue 2, Pages 134-146Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrm3737
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Funding
- Belgian grants (Interuniversity Attraction Poles) [IAP 7/32]
- Flemish grants (Research Foundation Flanders (FWO) [G.0875.11, FWO G.0973.11, FWO G.0A45.12N, FWO G.0787.13N]
- Ghent University grants (MRP, GROUP-ID consortium, Belgium)
- Foundation against Cancer
- Flanders Institute for Biotechnology
- Cancer Research UK programme grant
- European Research Council (ERC) Advanced Grant
- Wellcome Trust Senior Investigator Award, UK
- FWO
- German Society for Nephrology
- Novartis
- Pfizer
- Fresenius and the Hans-Werner Jackst dt Stiftung
- Marie Curie COFUND initiative
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Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein kinase 1)- and RIPK3-MLKL (mixed lineage kinase domain-like)-mediated necroptosis is the most understood form of regulated necrosis, other examples of this process are emerging, including cell death mechanisms known as parthanatos, oxytosis, ferroptosis, NETosis, pyronecrosis and pyroptosis. Elucidating how these pathways of regulated necrosis are interconnected at the molecular level should enable this process to be therapeutically targeted.
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