Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 15, Issue 11, Pages 722-734Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3885
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Funding
- EpiGeneSys NoE, ERC-Stg 'NuclearPotency'
- FP7 Marie-Curie Actions ITN Nucleosome4D
- EMBO YIP
- Fondation Schlumberger pour l'Education et la Recherche
- Fondation pour la Recherche Medicale
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Following fertilization, gametes undergo epigenetic reprogramming in order to revert to a totipotent state. How embryonic cells subsequently acquire their fate and the role of chromatin dynamics in this process are unknown. Genetic and experimental embryology approaches have identified some of the players and morphological changes that are involved in early mammalian development, but the exact events underlying cell fate allocation in single embryonic cells have remained elusive. Experimental and technological advances have recently provided novel insights into chromatin dynamics and nuclear architecture in single cells; these insights have reshaped our understanding of the mechanisms underlying cell fate allocation and plasticity in early mammalian development.
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