Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 16, Issue 1, Pages 5-17Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3915
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Funding
- Canadian Cancer Society
- Ontario Research Fund (ORF)
- Canadian Institute of Health Research
- Natural Science and Engineering Council of Canada (NSERC)
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Methylation of Lys and Arg residues on non-histone proteins has emerged as a prevalent post-translational modification and as an important regulator of cellular signal transduction mediated by the MAPK, WNT, BMP, Hippo and JAK-STAT signalling pathways. Crosstalk between methylation and other types of post-translational modifications, and between histone and non-histone protein methylation frequently occurs and affects cellular functions such as chromatin remodelling, gene transcription, protein synthesis, signal transduction and DNA repair. With recent advances in proteomic techniques, in particular mass spectrometry, the stage is now set to decode the methylproteome and define its functions in health and disease.
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