Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 11, Pages 699-712Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3679
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Funding
- National Institute of General Medical Sciences (NIGMS) [GM080465]
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The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (IncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.
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