Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 11, Pages 727-736Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3683
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Funding
- National Institute on Aging
- Ellison Foundation
- Molecular Biology of Neurodegeneration Training Grant from the National Institute of Neurological Disorders and Stroke
- MS Society
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Receptor-interacting protein 1 (RIP1) kinase has emerged as a key upstream regulator that controls inflammatory signalling as well as the activation of multiple cell death pathways, including apoptosis and necroptosis. The ability of RIP1 to modulate these key cellular events is tightly controlled by ubiquitylation, deubiquitylation and the interaction of RIP1 with a class of ubiquitin receptors. The modification of RIP1 may thus provide a unique 'ubiquitin code' that determines whether a cell activates nuclear factor-kappa B (NF-kappa B) to promote inflammatory signalling or induces cell death by apoptosis or necroptosis. Targeting RIP1 might be a novel therapeutic strategy for the treatment of both acute and chronic human diseases.
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