Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 9, Pages 581-591Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3639
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Funding
- Medical Research Council (MRC)
- European Research Council (ERC) (WNTEXPORT)
- Wellcome Trust [082694/z/07/z]
- Engineering and Physical Sciences Research Council (EPSRC) [EP/I017909/1]
- Microsoft Research Cambridge
- Wellcome Trust [082694/Z/07/Z] Funding Source: Wellcome Trust
- EPSRC [EP/I017909/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I017909/1] Funding Source: researchfish
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When fast-growing cells are confronted with slow-growing cells in a mosaic tissue, the slow-growing cells are often progressively eliminated by apoptosis through a process known as cell competition. The underlying signalling pathways remain unknown, but recent findings have shown that cell crowding within an epithelium leads to the eviction of cells from the epithelial sheet. This suggests that mechanical forces could contribute to cell elimination during cell competition.
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