Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 1, Pages 55-61Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3496
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Funding
- NCI NIH HHS [P30CA014195, P30 CA014195] Funding Source: Medline
- NIGMS NIH HHS [R01GM098749, R01 GM098749] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA014195] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM098749] Funding Source: NIH RePORTER
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Protein turnover is an effective way of maintaining a functional proteome, as old and potentially damaged polypeptides are destroyed and replaced by newly synthesized copies. An increasing number of intracellular proteins, however, have been identified that evade this turnover process and instead are maintained over a cell's lifetime. This diverse group of long-lived proteins might be particularly prone to accumulation of damage and thus have a crucial role in the functional deterioration of key regulatory processes during ageing.
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