Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 5, Pages 269-282Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3562
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Funding
- Novo Nordisk Foundation
- Danish Medical Research Council
- Lundbeck Foundation
- Danish Cancer Society
- Lundbeck Foundation [R34-2009-3790] Funding Source: researchfish
- Novo Nordisk Fonden [NNF12OC0002114] Funding Source: researchfish
- Novo Nordisk Foundation Center for Protein Research [PI Niels Mailand] Funding Source: researchfish
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Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA replication, providing a molecular platform that facilitates the myriad protein-protein and protein-DNA interactions that occur at the replication fork. Numerous PCNA-associated proteins compete for binding to a common surface on PCNA; hence these interactions need to be tightly regulated and coordinated to ensure proper chromosome replication and integrity. Control of PCNA-protein interactions is multilayered and involves post-translational modifications, in particular ubiquitylation, accessory factors and regulated degradation of PCNA-associated proteins. This regulatory framework allows cells to maintain a fine-tuned balance between replication fidelity and processivity in response to DNA damage.
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