Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 6, Pages 382-392Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3588
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Funding
- US National Institutes of Health [R01 GM101038, R01 GM52549]
- Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, Office of Science, U.S. DOE [DE-FG02-91ER20021]
- NASA [NNX12AN71G]
- National Science Foundation [MCB 0948584, 1243792]
- NASA [NNX12AN71G, 69794] Funding Source: Federal RePORTER
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1243792] Funding Source: National Science Foundation
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Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries and other transport factors are highly conserved across species, high-resolution imaging studies indicate that the organization of the ER-Golgi interface is varied in eukaryotic cells. Regulation of COPII assembly, in some cases to manage distinct cellular cargo, is emerging as one important component in determining this structure. Comparison of the ER-Golgi interface across different systems, particularly mammalian and plant cells, reveals fundamental elements and distinct organization of this interface. A better understanding of how these interfaces are regulated to meet varying cellular secretory demands should provide key insights into the mechanisms that control efficient trafficking of proteins and lipids through the secretory pathway.
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