Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 10, Pages 661-672Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3659
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Funding
- European Molecular Biology Organization (EMBO) long-term fellowship
- Krembil Foundation
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Single DNA lesions such as DNA double-strand breaks (DSBs) can cause cell death or trigger genome rearrangements that have oncogenic potential, and so the pathways that mend and signal DNA damage must be highly sensitive but, at the same time, selective and reversible. When initiated, boundaries must be set to restrict the DSB response to the site of the lesion. The integration of positive and, crucially, negative control points involving post-translational modifications such as phosphorylation, ubiquitylation and acetylation is key for building fast, effective responses to DNA damage and for mitigating the impact of DNA lesions on genome integrity.
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