Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 3, Pages 133-139Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3522
Keywords
-
Categories
Funding
- National Institutes of Health (NIH) [CA108941]
- Department of Defense [W81XWH-09-1-0279]
- National Cancer Institute [T32CA121938]
- Canadian Institute of Health Research (CIHR)
Ask authors/readers for more resources
Mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that is part of mTOR complex 1 (mTORC1), a master regulator that couples amino acid availability to cell growth and autophagy. Multiple cues modulate mTORC1 activity, such as growth factors, stress, energy status and amino acids. Although amino acids are key environmental stimuli, exactly how they are sensed and how they activate mTORC1 is not fully understood. Recently, a model has emerged whereby mTORC1 activation occurs at the lysosome and is mediated through an amino acid sensing cascade involving RAG GTPases, Ragulator and vacuolar H+-ATPase (v-ATPase).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available