Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 9, Pages 549-562Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3643
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Funding
- European Community [241548]
- MRC [MC_U105192711] Funding Source: UKRI
- Medical Research Council [MC_U105192711] Funding Source: researchfish
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Fertilization triggers a complex cellular programme that transforms two highly specialized meiotic germ cells, the oocyte and the sperm, into a totipotent mitotic embryo. Linkages between sister chromatids are remodelled to support the switch from reductional meiotic to equational mitotic divisions; the centrosome, which is absent from the egg, is reintroduced; cell division shifts from being extremely asymmetric to symmetric; genomic imprinting is selectively erased and re-established; and protein expression shifts from translational control to transcriptional control. Recent work has started to reveal how this remarkable transition from meiosis to mitosis is achieved.
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