Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 4, Pages 249-262Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3541
Keywords
-
Categories
Funding
- Fundacao para a Ciencia e a Tecnologia
- Instituto Gulbenkian de Ciencia
- European Research Council Starting Grant [2007-StG-208631]
Ask authors/readers for more resources
Wound healing is an essential biological process that comprises sequential steps aimed at restoring the architecture and function of damaged cells and tissues. This process begins with conserved damage signals, such as Ca2+, hydrogen peroxide (H2O2) and ATP, that diffuse through epithelial tissues and initiate immediate gene transcription-independent cellular effects, including cell shape changes, the formation of functional actomyosin structures and the recruitment of immune cells. These events integrate the ensuing transcription of specific wound response genes that further advance the wound healing response. The immediate importance of transcription-independent damage signals illustrates that healing a wound begins as soon as damage occurs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available