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Protein adaptation: mitotic functions for membrane trafficking proteins

Journal

NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 9, Pages 592-599

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3641

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Funding

  1. Senior Cancer Research Fellowship from Cancer Research UK [C25425/A15182]
  2. UK Biotechnology and Biological Sciences Research Council (BBSRC) [BB/H015582/1]
  3. BBSRC [BB/H015582/1] Funding Source: UKRI
  4. Biotechnology and Biological Sciences Research Council [BB/H015582/1] Funding Source: researchfish
  5. Cancer Research UK [15182] Funding Source: researchfish

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Membrane trafficking and mitosis are two essential processes in eukaryotic cells. Surprisingly, many proteins best known for their role in membrane trafficking have additional 'moonlighting' functions in mitosis. Despite having proteins in common, there is insufficient evidence for a specific connection between these two processes. Instead, these phenomena demonstrate the adaptability of the membrane trafficking machinery that allows its repurposing for different cellular functions.

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