Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 6, Pages 341-356Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3589
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Funding
- US National Institutes of health (NIH) [AI44432, HD065812, CA151535]
- California Institute of Regenerative Medicine [RM-01729]
- Leukemia and Lymphoma Society [TRP 6187- 12]
- National Library of Medicine, NIH
- National Science Foundation
- Jane Coffin Childs Memorial Fund for Medical Research
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In many organisms, the methylation of cytosine in DNA has a key role in silencing 'parasitic' DNA elements, regulating transcription and establishing cellular identity. The recent discovery that ten-eleven translocation (TET) proteins are 5-methylcytosine oxidases has provided several chemically plausible pathways for the reversal of DNA methylation, thus triggering a paradigm shift in our understanding of how changes in DNA methylation are coupled to cell differentiation, embryonic development and cancer.
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