Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 14, Issue 1, Pages 49-55Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3486
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Funding
- US National Institutes of Health (NIH) [DP1 GM105378, R01 GM088040, P50 HG005550]
- Jim and Ann Orr Massachusetts General Hospital Research Scholar Award
- NIH [T32CA009216]
- NATIONAL CANCER INSTITUTE [T32CA009216] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [P50HG005550] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM088040, DP1GM105378] Funding Source: NIH RePORTER
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Engineered nucleases enable the targeted alteration of nearly any gene in a wide range of cell types and organisms. The newly-developed transcription activator-like effector nucleases (TALENs) comprise a nonspecific DNA-cleaving nuclease fused to a DNA-binding domain that can be easily engineered so that TALENs can target essentially any sequence. The capability to quickly and efficiently alter genes using TALENs promises to have profound impacts on biological research and to yield potential therapeutic strategies for genetic diseases.
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